Research Faculty

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Publications
Selected Recent Publications

Ma, W., Nunes, I., Young, C.S.H. and Spector, A. Catalase enrichment using recombinant adenovirus protects aTN4-1 cells from H2O2. Free Rad. Biol. Med. 40, 335-340, 2006.

Andley, U.P. and Spector, A. Peroxide-resistance in human and mouse lens epithelial cell lines is related to long-term changes in cell biology and architecture. Free Rad. Biol. Med. 39, 797-810, 2005.

Li, D., Ma, W., Sun, F., Pavlidis, P. and Spector, A. Cluster analysis of genes with significant change in expression in cells conditioned to survive TBOOH. Exp. Eye Res. 78, 301-308, 2004.

Ma, W., Li, D., Sun, F., Kleiman, N.J. and Spector, A.  The effect of stress withdrawal upon the gene expression and certain biochemical and cell biological properties of peroxide-conditioned cell lines.  FASEB J. 18, 480-488, 2004.

Ma, W., Kleiman, N.J., Sun, F., Li, D. and Spector, A. Peroxide toxicity in conditioned lens epithelial cells – Evaluation of multi-defense systems. Exp. Eye Res. 77, 711-720, 2003.

Spector, A., Li, D., Ma, W., Sun, F. and Pavlidis, P. Differential amplification of gene expression in lens cell lines conditioned to survive peroxide stress. Invest. Ophthalmol. Vis. Sci. 43, 3251-3264. 2002.

Spector, A., Ma, W., Sun, F., Li, D. and Kleiman, N.J. The effect of H2O2 and tertiary butyl hydroperoxide upon a murine immortal lens epithelial cell line, aTN4-1. Exp. Eye Res. 75, 573-582, 2002.

Spector, A., Wang, R-R, Ma, W. and Kleiman, NJ. Development and characterization of a H2O2 resistant immortal lens epithelial cell line. Invest. Ophthalmol. Vis. Sci. 41, 832-843, 2000.

Yang, Y., Spector, A., Ma, W., Wang, R.-R., Larsen, K. and Kleiman, N.J. The effect of catalase amplification on immortal lens epithelial cell lines. Exp. Eye Res. 67, 647-656, 1998.

Spector, A., Ho, Y-S., Wang, R-R., Ma, W., Yang, Y. and Li, W-C.  Evaluation of the antiperoxide defense system of the lens utilizing GSH peroxidase transgenics and knockouts. In Oxidative Stress, Cancer, AIDS, and Neurodegenerative Diseases (Montagnier, Olivier and Pasquier, eds.) Chapter 48, Pp. 507-515, 1998, Marcel Dekker, Inc., New York.

Spector, A. Oxidative stress induced cataract: Mechanism of action. FASEB J. 9, 1173-1182, 1995.

Spector, A., Wang, G-M., Wang, R-R., Li, W-C. and Kuszak, J.R. A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. I. Transparency and Epithelial Cell Layer. Exp. Eye Res. 60, 471-481, 1995.

Spector, A., Wang, G-M., Wang, R-R., Li, W-C. and Kleiman, N.J. A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. II. Mechanism of Action. Exp. Eye Res. 60, 483-492, 1995.

Garner, M.H. and Spector, A. ATP hydrolysis kinetics by Na,K-ATPase in cataract. Exp. Eye Res. 42, 339-458, 1986.

Spector, A. The search for a solution to senile cataracts - Proctor Lecture. Invest. Ophthal. Vis. Sci. 25, 130-146, 1984.

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